P-154: Comparison of Pregnancy Outcome between Low Dose HCG in Late Follicular Phase in GnRH Long Protocol and Standard Long Protocol in ART Cycles

Background: A safe, simple and cost-effective protocol is important goal in ART cycles. The aim of this prospective study was whether administration of low dose HCG in late follicular phase can be used clinically to replace gonadotropins administration in GnRH long protocol. Materials and Methods: 69 patients who were candidate for assisted reproductive technology (ART) enrolled the study and randomly divided into two groups. The control group (n=38) received standard long protocol and gonadotropins administration were continued until the day of HCG injection (10000 IU) for final follicular maturation. The study group (n=31) received GnRH long protocol and when at least ≥ 6 follicles with mean diameter ≥ 13 mm were observed in both ovaries, gonadotropins administration were discontinued and low dose HCG 200 IU daily was started and was continued until the day of HCG injection (10000 IU) for final follicular maturation. Results: There were no significant differences in age, basal FSH, infertility duration and infertility etiology in two groups. There were no statistical differences between two groups regarding to chemical pregnancy, clinical pregnancy, ongoing pregnancy, abortion, and multiple pregnancy rates per transfer between two groups (48%, 36%, 36%, 8%, and 4% in study group vs. 54.3%, 25.7%, 25.7%, 17.1% and 5.7% in control group, respectively). Mean doses of used gonadotropins were significantly higher in control group than that in study group and were 2524 ± 893 IU in control group and 1439 ± 433 IU in study group (p=0.000). Conclusion: According to our data, we recommended use of low dose HCG in GnRH long protocol because of lower doses of used gonadotropins and its more costeffectiveness.